It is a type of fracture with no callus formation or lack of consolidation after 9 or more months from the initial fracture. It is also known as a pseudoarthrosis, a nonunion fracture, a not consolidated fracture or a delayed healing fracture.
We are studying the effect of stem cells in the healing of long bone (femur, tibia, humerus) fractures that do not heal. This is a novel treatment for non-union fractures that uses stem cells, a type of the patient´s own cells that have the ability to regenerate bone and other tissues. In this study, the effect of the cells is compared against the standard treatment, the bone graft of the patient’s own iliac crest. In both treatments, surgical procedures for non-union fractures are performed.
The study has the necessary approvals from the Medicines Agencies and the Ethics Committee.
In Spain, the study is carried out in several hospitals in the Autonomous Region of Madrid. Other centers in Italy, Germany and France also participate.